I play both PLO and NLHE, PLO would be my main game if it was more of a regular spread here.
So what I'll start with it the amount of NLHE players who jump to PLO, with the attitude of I play NLHE well and it's basically the same with two extra cards so it should be easy to do well, who then go broke extremely quick. The point of this is to highlight that NLHE and PLO are extremely different games in how they play. You cannot play PLO well with a NLHE mindset. You might get lucky and think that NLHE mindset works, but PLO has a much higher variance so it'll catch up to you quickly.
My advice to you would be to learn NLHE first and transfer over, because, even though I said they're different, the core game is the same, as in what hands beat what. NLHE is also more common than PLO, the only time of the year you might have more PLO tables than NLHE is during the PLO events during the WSOP, and even then maybe only for a few hours. To get good at poker it's about volume of hands, learning from your mistakes and using your hand history to make better, more informed decisions in the future. Because NLHE is played more you'll get more experience at this playing NLHE than playing PLO.
Now how to transition over to PLO from NLHE, some of my advice would be:
- Don't fall in love with a two card hand, you have 4 cards. For
example J,J,6,9 plays worse than a hand like 6,7,8,9. PLO is at it's
core a game about really solid poker fundamentals, you might see
crazy PLO hands from a WSOP event, but don't forget those guys and
gals on the TV have millions of hands and know when to bend those
fundamentals.
- It's all about the odds and making ONLY +EV decisions. It might seem PLO is more forgiving than NLHE on making bad EV decisions, but it's not. Play 10,000 hands making -EV decisions and see just how 'forgiving' PLO is.
- Tight is right, especially for NLHE players coming into PLO. A PLO player loves NLHE players coming into their game, NLHE players fall in love with aces and then are shocked when they're beaten by a hand like 9♥T♥J♠Q♠. Don't open up your game and put yourself in bad situations. Stick to solid 4 card hands, double suited connectors.