I realized early in my philosophic journey, that how we know what we know, was a VERY critical question. Disagreements over how one should do epistemology, put too many philosophic investigations or dialogs off track from the outset.
The question can best be addressed as a pragmatic one -- how can we be most effective in resolving philosophic disputes or questions?
I found that of the methods I have seen used, those of methodological naturalism seem to be the most useful. Threat philosophic questions similarly to how one would treat science questions, and try to spell out a problem, a hypothesis about that problem, figure out ways to test the (or many) hypothesis(es), modify or reject hypotheses that fail tests, and iteratively approach better and better understanding, and plausibly consensus. This is the Popperian approach.
Popper offers a significant improvement over his predecessors, Hume and the Logical Positivists. Hume's rationalist perfectionism threw doubt on this whole methodology (solved by adopting pragmatism instead), and the LP focus on confirmations was VERY susceptible to confirmation bias.
As with all of philosophy, other philosophers have critiqued Popper, and found that falsifiability is not possible in absolute terms (Quine), that scientists don't really abide by it (Kuhn), and that there are exceptions in the way science is actually done (Feyerabend).
In response to these critiques, Popper reformulated his thinking in terms of a network of claims, with central and ancillary statements in the hypothesis family. Popper's reformulation works pretty well, but Lakatos's concept of Research Programmes does an even better job of describing how science both can and should operate: http://www.mantleplumes.org/Lakatos.html
In a Research Programme approach, we adopt it if it is explanatorily useful, and has few and declining problem areas, and there are not better Research Programmes available to us. We then abandon it when the problems are long term, and accumulating, and there are better options.
Problems, and their resolution, can be approximated by falsifications, refutations, statistical confidence, etc. But trying to formulate these concepts explicitly fails. Lakatos' efforts to define progressivity and regressivity in explicit terms, were shown to have logical faults. Same with Popper's efforts to show that science theories incrementally approach truth (increasing verisimilitude) -- this too was shown to have logic faults.
We therefore are forced to operate off judgement, and the intersubjective consensus of people OF good judgement. Applying judgement to Research programs, solutions vs problems, progressivity vs. regressivity, is not that hard for easy cases, and for hard/marginal cases-- we probably SHOULD have multiple competing research programmes running concurrently!
This is a pragmatic, judgement based approach to epistemology. But it is one that follows a set of principles that are FAR more useful than unstructured convictions.
Popper's falsifiability is a good first approximation approach to doing epistemology, and the masters level class is Lakatos' Research Programmes.