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Is it possible in Windows 10 home (maybe through group policies?) to restrict or outright block specific applications from ever accessing specific physical drives?

Jeffrey
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  • See if the following link can help you :https://superuser.com/questions/677114/deny-application-access-to-hard-drive-or-volume-in-windows-7 – Candy Dec 04 '20 at 07:16

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(Which version of Windows?)

In the general case, you will need to run the application under a specific user account and limit its access to the root folder of the disk(s).

For more information see this Microsoft article : Access Control Overview.

On Windows Server you may use Group Policies.
See the article How to Assign Permissions to Files and Folders through Group Policy.

harrymc
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